Publications 2017 
 Original Paper
 
 
Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation. 
Tsuchida K, Tsujita T, Hayashi M, Ojima A, Keleku-Lukwete N, Katsuoka F, Otsuki A, Kikuchi H, Oshima Y, Suzuki M, Yamamoto M.
Free Radic Biol Med.   103, 236-247  (2017)
大学院生の土田恒平さんの論文です
 
Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression. 
Nezu M, Souma T, Yu L, Suzuki T, Saigusa D, Ito S, Suzuki N, Yamamoto M.
Kidney Int.   91, 387-401  (2017)
卒業生の祢津昌広さんの論文です
 
The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin. 
Hidaka T, Ogawa E, Kobayashi EH, Suzuki T, Funayama R, Nagashima T, Fujimura T, Aiba S, Nakayama K, Okuyama R, Yamamoto M.
Nat Immunol.   18, 64-73  (2017)
卒業生の日高高徳さんの論文です
 
Derepression of the DNA methylation machinery of Gata1 gene triggers the differentiation cue for erythropoiesis. 
Yu L, Takai J, Otsuki A, Katsuoka F, Suzuki M, Katayama S, Nezu M, Engel JD, Moriguchi T, Yamamoto M.
Mol Cell Biol.   37, e00592-16  (2017)
研究員の干磊さんの論文です
 
Nrf2 improves leptin and insulin resistance provoked by hypothalamic oxidative stress. 
Yagishita Y, Uruno A, Fukutomi T, Saito R, Saigusa D, Pi J, Fukamizu A, Sugiyama F, Takahashi S, Yamamoto M.
Cell Reports   18, 2030-2044  (2017)
研究員の柳下陽子さんの論文です
 
Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus 
Suzuki T, Seki S, Hiramoto K, Naganuma E, Kobayashi EH, Yamaoka A, Baird L, Takahashi N, Sato H, Yamamoto M.
Nat Commun.    Feb 24;8, 14577  (2017)
鈴木隆史講師の論文です
 
The novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in mice. 
Higashi C, Kawaji A, Tsuda N, Hayashi M, Saito R, Yagishita Y, Suzuki T, Uruno A, Nakamura M, Nakao K, Furusako S, Yamamoto M.
Eur J Pharmacol   802, 76-84  (2017)
持田製薬研究員の東知佳さんの論文です
 
GATA2 haploinsufficiency accelerates EVI1-driven leukemogenesis. 
Katayama S, Suzuki M, Yamaoka A, Keleku-Lukwete N, Katsuoka F, Otsuki A, Kure S, Engel JD, Yamamoto M.
Blood   130, 908-919  (2017)
大学院生の片山紗乙莉さんの論文です
 
NRF2 activation impairs quiescence and bone marrow reconstitution capacity of hematopoietic stem cells. 
Murakami S, Suzuki T, Harigae H, Romeo PH, Yamamoto M, Motohashi H.
Mol Cell Biol.     (2017)
 
NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology. 
Rojo AI, Pajares M, Rada P, Nuñez A, Nevado-Holgado AJ, Killik R, Van Leuven F, Ribe E, Lovestone S, Yamamoto M, Cuadrado A.
Redox Biol.   13, 444-451  (2017)
 
Reducing inflammatory cytokine production from renal collecting duct cells by inhibiting GATA2 ameliorates acute kidney injury. 
Yu L, Moriguchi T, Kaneko H, Hayashi M, Hasegawa A, Nezu M, Saya H, Yamamoto M, Shimizu R.
Mol Cell Biol.     (2017)
研究員の于磊さんの論文です
 
Induction of erythropoietin gene expression in epithelial cells by chemicals identified in GATA inhibitor screenings. 
Kaneko H, Katoh T, Hirano I, Hasegawa A, Tsujita T, Yamamoto M, Shimizu R.
Genes Cells.   22, 939-952  (2017)

 Review
 
 
The KEAP1-NRF2 System in Cancer. 
Taguchi K, Yamamoto M.
Front Oncol.   7, 85  (2017)
田口恵子講師の総説です
 
Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression. 
Nezu M, Suzuki N, Yamamoto M.
Am J Nephrol.   45, 473-483  (2017)
卒業生の祢津昌広さんの総説です
 
Stress-sensing mechanisms and the physiological roles of the Keap1-Nrf2 system during cellular stress. 
Suzuki T, Yamamoto M.
J Biol Chem.   292, 16817-16824  (2017)
鈴木隆史講師の総説です

 日本語著書 (Publications in Japanese)
 
 
低酸素ストレスに対する生体応答機構 
平野育生, 山本雅之.
ファルマシア   53, 201-205  (2017)
 
ストレス応答制御(第16章) 
鈴木未来子, 山本雅之.
遺伝子発現制御—クロマチン, 転写制御, エピジェネティクスー   167-175  (2017)
 
糖尿病におけるKEAP1-NRF2系の役割 
宇留野晃, 山本雅之.
DIABETES JOUNAL   45, 35-40  (2017)
宇留野晃講師の総説です

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