| Transcription factor Nrf2 activation regulates NETosis, endothelial injury, and kidney disease in myeloperoxidase-positive antineutrophil cytoplasmic antibody-associated vasculitis | | Ueda Y, Nakazawa D, Nishio S, Shiratori-Aso S, Kudo T, Miyoshi-Harashima A, Watanabe-Kusunoki K, Hattanda F, Iwasaki S, Tsuji T, Tomaru U, Aratani Y, Yamamoto M, Ishizu A, Atsumi T. | Kidney Int. , (2024) | | |
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| Effects of NRF2 polymorphisms on safety and efficacy of bardoxolone methyl: subanalysis of TSUBAKI study | | Ikejiri K, Suzuki T, Muto S, Takama H, Yamawaki K, Miyazawa T, Urakawa I, Aoki Y, Otsuki A, Katsuoka F, Kinoshita K, Nangaku M, Akizawa T, Yamamoto M. | Clin Exp Nephrol. 28(3), 225-234 (2024) | | |
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| Next-generation sequencing analysis with a population-specific human reference genome. | | Suzuki T, Ninomiya K, Funayama T, Okamura Y, Tadaka S; Tohoku Medical Megabank Project Study Group; Kinoshita K, Yamamoto M, Kure S, Kikuchi A, Tamiya G, and Takayama J. | Genes Genet Syst 99., (2024) | | |
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| Specific cancer types and prognosis in patients with variations in the KEAP1-NRF2 system: A retrospective cohort study. | | Iwasaki T, Shirota H, Sasaki K, Ouchi K, Nakayama Y, Oshikiri H, Otsuki A, Suzuki T, Yamamoto M, and Ishioka C. | Cancer Sci. 115 (12), 4034-4044. (2024) | | |
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| GWAS Meta-analysis of Kidney Function Traits in Japanese Populations. | | 38. Hishida A, Nakatochi M, Sutoh Y, Nakano S, Momozawa Y, Narita A, Tanno K, Shimizu A, Hozawa A, Kinoshita K, Yamaji T, Goto A, Noda M, Sawada N, Ikezaki H, Nagayoshi M, Hara M, Suzuki S, Koyama T, Koriyama C, Katsuura-Kamano S, Kadota A, Kuriki K, Yamamoto M, Sasaki M, Iwasaki M, Matsuo K, and Wakai K. | J Epidemiol. 34(11), 526-534 (2024) | | |
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| The NRF2 inducer CDDO-2P-Im provokes a reduction in amyloid β levels in Alzheimer's disease model mice. | | Uruno A, Kadoguchi-Igarashi S, Saito R, Koiso S, Saigusa D, Chu CT, Suzuki T, Saito T, Saido TC, Cuadrado A, and Yamamoto M. | J Biochem. 176 (5), 405-414. (2024) | | |
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| Estrogen, via ESR2 receptor, prevents oxidative stress-induced Müller cell death and stimulates FGF2 production independently of NRF2, attenuating retinal degeneration. | | Tawarayama H, Uchida K, Hasegawa H, Yoshida M, Inoue-Yanagimachi M, Sato W, Himori N, Yamamoto M, and Nakazawa T. | Exp Eye Res. 248, 110103. (2024) | | |
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| Sensor systems of KEAP1 uniquely detecting oxidative and electrophilic stresses separately in vivo. | | Sato M, Yaguchi N, Iijima T, Muramatsu A, Baird L, Suzuki T, and Yamamoto M. | Redox Biol. 77, 103355. (2024) | | |
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| Identification of risk loci for postpartum depression in a genome-wide association study. | | Li X, Takahashi N, Narita A, Nakamura Y, Sakurai-Yageta M, Murakami K, Ishikuro M, Obara T, Kikuya M, Ueno F, Metoki H, Ohseto H, Takahashi I, Nakamura T, Warita N, Shoji T, Yu Z, Ono C, Kobayashi N, Kikuchi S, Matsuki T, Nagami F, Ogishima S, Sugawara J, Hoshiai T, Saito M, Fuse N, Kinoshita K, Yamamoto M, Yaegashi N, Ozaki N, Tamiya G, Kuriyama S, and Tomita H. | Psychiatry Clin Neurosci. 78(11), 712-720. (2024) | | |
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| Mutations of CYP1B1 and FOXC1 genes for childhood glaucoma in Japanese individuals. | | Fuse N, Kimura M, Shimizu A, Koshiba S, Hamanaka T, Nakamura M, Ishida N, Sakai H, Ikeda Y, Mori K, Endo A, Nagasaki M, Katsuoka F, Yasuda J, Matsubara Y, Nakazawa T, and Yamamoto M. | Jpn J Ophthalmol. 68(6), 688-701. (2024) | | |
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| Genetic Risk, Lifestyle Adherence, and Risk of Developing Hyperuricaemia in a Japanese Population. | | Takase M, Nakaya N, Nakamura T, Kogure M, Hatanaka R, Nakaya K, Chiba I, Tokioka S, Kanno I, Nochioka K, Tsuchiya N, Hirata T, Narita A, Obara T, Ishikuro M, Ohseto H, Uruno A, Kobayashi T, Kodama EN, Hamanaka Y, Orui M, Ogishima S, Nagaie S, Fuse N, Sugawara J, Kuriyama S, Matsuda BJPK, Izumi Y, Kinoshita K, Tamiya G, Hozawa A, Yamamoto M and ToMMo investigators. | Rheumatology (Oxford). keae492. , (2024) | | |
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| Validity and reproducibility of food group intakes in a self-administered food frequency questionnaire for genomic and omics research: the Tohoku Medical Megabank Project. | | Murakami K, Ishihara J, Takachi R, Sugawara S, Aizawa M, Takahashi I, Obara T, Ishikuro M, Noda A, Ogino M, Hoshina Y, Kito K, Nakadate M, Maruya S, Matsuno T, Yonezawa Y, Yamashita T, Suzuki S, Yamamoto M, and Kuriyama S. | J Epidemiol. , (2024) | | |
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| Progress Report of the Tohoku Medical Megabank Community-based Cohort Study: Study Profile of the Repeated Center-based Survey During Second Period in Miyagi Prefecture. | | Hozawa A, Nakaya K, Nakaya N, Nakamura T, Kogure M, Hatanaka R, Chiba I, Kanno I, Sugawara J, Kodama E, Hamanaka Y, Kobayashi T, Uruno A, Tsuchiya N, Hirata T, Narita A, Tsuboi A, Tamahara T, Otsuki A, Goto M, Taira M, Shimizu R, Suzuki K, Obara T, Kikuya M, Metoki H, Ishikuro M, Danjoh I, Ogishima S, Nagaie S, Minegishi N, Hiratsuka M, Kumada K, Nishijima I, Nobukuni T, Yamaguchi-Kabata Y, Nagami F, Kure S, Fuse N, Kinoshita K, Izumi Y, Kuriyama S, and Yamamoto M. | J Epidemiol. 34 (9), 434-443. (2024) | | |
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| Plasma biomarkers of neurodegeneration in patients and high risk subjects with Lewy body disease. | | Hiraga K, Hattori M, Satake Y, Tamakoshi D, Fukushima T, Uematsu T, Tsuboi T, Sato M, Yokoi K, Suzuki K, Arahata Y, Washimi Y, Hori A, Yamamoto M, Shimizu H, Wakai M, Tatebe H, Tokuda T, Nakamura A, Niida S, and Katsuno M. | NPJ Parkinsons Dis. 10(1), 135. (2024) | | |
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| Kodama EN, Taira M, Kiyomoto H, Nakamura T, Nagaie S, Kuriyama S, Hozawa A, Sugawara J, Nagami F, Uruno A, Nakaya J, Metoki H, Sakaida M, Kikuya M, Suzuki Y, Ito K, Hamanaka Y, Suzuki K, Kure S, Yaegashi N, Fuse N, Shimizu R, and Yamamoto M. | | Urgent Notification Intervention of Home Blood Pressure in Cohort Studies of the Tohoku Medical Megabank Project. | JMA J. 7(3), 342-352. (2024) | | |
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| Identifying critical age and gender-based metabolomic shifts in a Japanese population of the Tohoku Medical Megabank cohort. | | Sakurai M, Motoike IN, Hishinuma E, Aoki Y, Tadaka S, Kogure M, Orui M, Ishikuro M, Obara T, Nakaya N, Kumada K, Hozawa A, Kuriyama S, Yamamoto M, Koshiba S, and Kinoshita K. | Sci Rep. 14(1), 15681. (2024) | | |
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| How Healthy Lifestyle Habits Have Interacted with SARS-CoV-2 Infection and the Effectiveness of COVID-19 Vaccinations: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. | | Orui M, Obara T, Ishikuro M, Noda A, Shinoda G, Murakami K, Nakamura T, Metoki H, Ogishima S, Izumi Y, Nakaya N, Hozawa A, Ishii T, Nagami F, Yamamoto M, and Kuriyama S. | JMA J. 7(3), 353-363. (2024) | | |
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| Associations of combined genetic and lifestyle risks with hypertension and home hypertension. | | Takase M, Hirata T, Nakaya N, Nakamura T, Kogure M, Hatanaka R, Nakaya K, Chiba I, Kanno I, Nochioka K, Tsuchiya N, Narita A, Metoki H, Satoh M, Obara T, Ishikuro M, Ohseto H, Uruno A, Kobayashi T, Kodama EN, Hamanaka Y, Orui M, Ogishima S, Nagaie S, Fuse N, Sugawara J, Kuriyama S, Tamiya G, Hozawa A, Yamamoto M and ToMMo investigators. | Hypertens Res. 47(8), 2064-2074. (2024) | | |
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| Genetic Risk, Healthy Lifestyle Adherence, and Risk of Developing Diabetes in the Japanese Population. | | Takase M, Nakaya N, Nakamura T, Kogure M, Hatanaka R, Nakaya K, Chiba I, Kanno I, Nochioka K, Tsuchiya N, Hirata T, Narita A, Obara T, Ishikuro M, Uruno A, Kobayashi T, Kodama EN, Hamanaka Y, Orui M, Ogishima S, Nagaie S, Fuse N, Sugawara J, Kuriyama S; BioBank Japan Project; Matsuda K, Izumi Y, Kinoshita K, Tamiya G, Hozawa A, Yamamoto M, ToMMo investigators. | J Atheroscler Thromb. 31(12), 1717-1732. (2024) | | |
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| Activation of NOTCH signaling impedes cell proliferation and survival in acute megakaryoblastic leukemia. | | Ong KOK, Mok MMH, Niibori-Nambu A, Du L, Yanagida M, Wang CQ, Bahirvani AG, Chin DWL, Koh CP, Ng KP, Yamashita N, Jacob B, Yokomizo T, Takizawa H, Matsumura T, Suda T, Lau JA, Tan TZ, Mori S, Yang H, Iwasaki M, Minami T, Asou N, Sun QY, Ding LW, Koeffler HP, Tenen DG, Shimizu R, Yamamoto M, Ito Y, Kham SKY, Yeoh AE, Chng WJ, and Osato M. | Exp Hematol. 137, 104255. (2024) | | |
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| A fine-scale genetic map of the Japanese population. | | Takayama J, Makino S, Funayama T, Ueki M, Narita A, Murakami K, Orui M, Ishikuro M, Obara T; Tohoku Medical Megabank Project Study Group; Kuriyama S, Yamamoto M, and Tamiya G., A fine-scale genetic map of the Japanese population. | Clin Genet. 106(3), 284-292. (2024) | | |
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| Early prediction of hypertensive disorders of pregnancy toward preventive early intervention. | | Mizuno S, Nagaie S, Sugawara J, Tamiya G, Obara T, Ishikuro M, Kuriyama S, Yaegashi N, Tanaka H, Yamamoto M, and Ogishima S. | AJOG Glob Rep. 2024 Jul 27; 4(4): 100383. 4(4), 100383. (2024) | | |
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| Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction. | | Siew K, Nestler KA, Nelson C, D'Ambrosio V, Zhong C, Li Z, Grillo A, Wan ER, Patel V, Overbey E, Kim J, Yun S, Vaughan MB, Cheshire C, Cubitt L, Broni-Tabi J, Al-Jaber MY, Boyko V, Meydan C, Barker P, Arif S, Afsari F, Allen N, Al-Maadheed M, Altinok S, Bah N, Border S, Brown AL, Burling K, Cheng-Campbell M, Colón LM, Degoricija L, Figg N, Finch R, Foox J, Faridi P, French A, Gebre S, Gordon P, Houerbi N, Valipour Kahrood H, Kiffer FC, Klosinska AS, Kubik A, Lee HC, Li Y, Lucarelli N, Marullo AL, Matei I, McCann CM, Mimar S, Naglah A, Nicod J, O'Shaughnessy KM, Oliveira LC, Oswalt L, Patras LI, Lai Polo SH, Rodríguez-Lopez M, Roufosse C, Sadeghi-Alavijeh O, Sanchez-Hodge R, Paul AS, Schittenhelm RB, Schweickart A, Scott RT, Choy Lim Kam Sian TC, da Silveira WA, Slawinski H, Snell D, Sosa J, Saravia-Butler AM, Tabetah M, Tanuwidjaya E, Walker-Samuel S, Yang X, Yasmin, Zhang H, Godovac-Zimmermann J, Sarder P, Sanders LM, Costes SV, Campbell RAA, Karouia F, Mohamed-Alis V, Rodriques S, Lynham S, Steele JR, Baranzini S, Fazelinia H, Dai Z, Uruno A, Shiba D, Yamamoto M, A C Almeida E, Blaber E, Schisler JC, Eisch AJ, Muratani M, Zwart SR, et al. | Nature Commun. 15 (1), 4923. (2024) | | |
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| Body mass index stratification optimizes polygenic prediction of type 2 diabetes in cross-biobank analyses. | | Ojima T, Namba S, Suzuki K, Yamamoto K, Sonehara K, Narita A; Tohoku Medical Megabank Project Study Group; Biobank Japan Project; Kamatani Y, Tamiya G, Yamamoto M, Yamauchi T, Kadowaki T, and Okada Y. Body mass index stratification optimizes polygenic prediction of type 2 diabetes in cross-biobank analyses. | Nature Genet. 56(6), 1100-1109. (2024) | | |
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| The drug-specific properties of hypoxia-inducible factor-prolyl hydroxylase inhibitors in mice reveal a significant contribution of the kidney compared to the liver to erythropoietin induction. | | Nakai T, Saigusa D, Kato K, Fukuuchi T, Koshiba S, Yamamoto M, and Suzuki N. | Life Sci. 346:, 122641. (2024) | | |
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| PNPO-PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity. | | Sekine H, Takeda H, Takeda N, Kishino A, Anzawa H, Isagawa T, Ohta N, Murakami S, Iwaki H, Kato N, Kimura S, Liu Z, Kato K, Katsuoka F, Yamamoto M, Miura F, Ito T, Takahashi M, Izumi Y, Fujita H, Yamagata H, Bamba T, Akaike T, Suzuki N, Kinoshita K, and Motohashi H. | Nature Metab. 6(6), 1108-1127. (2024) | | |
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| Whole blood transcriptome analysis for age- and gender-specific gene expression profiling in Japanese individuals. | | Aoki YI, Taguchi K, Anzawa H, Kawashima J, Ishida N, Otsuki A, Hasegawa A, Baird L, Suzuki T, Motoike IN, Ohneda K, Kumada K, Katsuoka F, Kinoshita K, and Yamamoto M. | J Biochem. 175(6), 611-627. (2024) | | |
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| Bag1 protein loss sensitizes mouse embryonic fibroblasts to glutathione depletion. | | Inose-Maruyama A, Irokawa H, Takeda K, Taguchi K, Morita M, Yamamoto M, Sasaki M, and Kuge S. | Cell Stress Chaperones. 29 (3), 497-509. (2024) | | |
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| The gut lactic acid bacteria metabolite, 10-oxo-cis-6,trans-11-octadecadienoic acid, suppresses inflammatory bowel disease in mice by modulating the NRF2 pathway and GPCR-signaling. | | Ando M, Nagata K, Takeshita R, Ito N, Noguchi S, Minamikawa N, Kodama N, Yamamoto A, Yashiro T, Hachisu M, Ichihara G, Kishino S, Yamamoto M, Ogawa J, and Nishiyama C. | Front Immunol. 15, 1374425. (2024) | | |
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| Differential squamous cell fates elicited by NRF2 gain of function versus KEAP1 loss of function. | | Takahashi J, Suzuki T, Sato M, Nitta S, Yaguchi N, Muta T, Tsuchida K, Suda H, Morita M, Hamada S, Masamune A, Takahashi S, Kamei T, and Yamamoto M. | Cell Rep. 43 (4), 114104. (2024) | | |
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| Metabolic reprogramming in Nrf2-driven proliferation of normal rat hepatocytes. | | Kowalik MA, Taguchi K, Serra M, Caddeo A, Puliga E, Bacci M, Koshiba S, Inoue J, Hishinuma E, Morandi A, Giordano S, Perra A, Yamamoto M, and Columbano A. | Hepatology. 79(4), 829-843. (2024) | | |
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| Effects of NRF2 polymorphisms on safety and efficacy of bardoxolone methyl: subanalysis of TSUBAKI study. | | Ikejiri K, Suzuki T, Muto S, Takama H, Yamawaki K, Miyazawa T, Urakawa I, Aoki Y, Otsuki A, Katsuoka F, Kinoshita K, Nangaku M, Akizawa T, and Yamamoto M. | Clin Exp Nephrol. 28 (3), 225-234. (2024) | | |
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| Development of phenotyping algorithms for hypertensive disorders of pregnancy (HDP) and their application in more than 22,000 pregnant women. | | Mizuno S, Wagata M, Nagaie S, Ishikuro M, Obara T, Tamiya G, Kuriyama S, Tanaka H, Yaegashi N, Yamamoto M, Sugawara J, and Ogishima S. | Sci Rep. 14(1), 6292. (2024) | | |
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| Dietary habits and plasma lipid concentrations in a general Japanese population. | | Sato M, Hishinuma E, Matsukawa N, Shima Y, Saigusa D, Motoike IN, Kogure M, Nakaya N, Hozawa A, Kuriyama S, Yamamoto M, Koshiba S, and Kinoshita K. | Metabolomics. 20 (2), 34. (20224) | | |
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| The Health History of First-Degree Relatives' Dyslipidemia Can Affect Preferences and Intentions following the Return of Genomic Results for Monogenic Familial Hypercholesterolemia. | | Tokutomi T, Yoshida A, Fukushima A, Yamamoto K, Ishigaki Y, Kawame H, Fuse N, Nagami F, Suzuki Y, Sakurai-Yageta M, Uruno A, Suzuki K, Tanno K, Ohmomo H, Shimizu A, Yamamoto M, and Sasaki M. | Genes (Basel). 15(3), 384. (2024) | | |
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| Strain-dependent modifiers exacerbate familial leukemia caused by GATA1-deficiency. | | Hirano I, Abe K, Engel JD, Yamamoto M, and Shimizu R. | Exp Hematol Oncol. 13 (1), 23. (2024) | | |
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| The abundance of the short GATA1 isoform affects megakaryocyte differentiation and leukemic predisposition in mice. | | Ishihara D, Hasegawa A, Hirano I, Engel JD, Yamamoto M, Shimizu R. | Exp Hematol Oncol. 13(1), 24. (2024) | | |
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| Prevalence, Associated Factors, and Inter-Eye Differences of Refractive Errors in a Population-Based Japanese Cohort: The Tohoku Medical Megabank Eye Study, | | Miki A, Fuse N, Fujimoto S, Taira M, Saito T, Okazaki T, Shiraki A, Sato S, Kawasaki R, Nakamura T, Kinoshita K, Nishida K, and Yamamoto M. | Ophthalmic Epidemiol 31 (1), 46-54. (2024) | | |
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| Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses. | | Shiraishi K, Takahashi A, Momozawa Y, Daigo Y, Kaneko S, Kawaguchi T, Kunitoh H, Matsumoto S, Horinouchi H, Goto A, Honda T, Shimizu K, Torasawa M, Takayanagi D, Saito M, Saito A, Ohe Y, Watanabe SI, Goto K, Tsuboi M, Tsuchihara K, Takata S, Aoi T, Takano A, Kobayashi M, Miyagi Y, Tanaka K, Suzuki H, Maeda D, Yamaura T, Matsuda M, Shimada Y, Mizuno T, Sakamoto H, Yoshida T, Goto Y, Yoshida T, Yamaji T, Sonobe M, Toyooka S, Yoneda K, Masago K, Tanaka F, Hara M, Fuse N, Nishizuka SS, Motoi N, Sawada N, Nishida Y, Kumada K, Takeuchi K, Tanno K, Yatabe Y, Sunami K, Hishida T, Miyazaki Y, Ito H, Amemiya M, Totsuka H, Nakayama H, Yokose T, Ishigaki K, Nagashima T, Ohtaki Y, Imai K, Takasawa K, Minamiya Y, Kobayashi K, Okubo K, Wakai K, Shimizu A, Yamamoto M, Iwasaki M, Matsuda K, Inazawa J, Shiraishi Y, Nishikawa H, Murakami Y, Kubo M, Matsuda F, Kamatani Y, Hamamoto R, Matsuo K, and Kohno T. | Cancer Commun (Lond). 44 (2), 287-293. (2024) | | |
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| Dietary melatonin and liver cancer incidence in Japan: From the Takayama study. | | Wada K, Hattori A, Maruyama Y, Mori T, Sugino M, Nakashima Y, Yamakawa M, Yamamoto M, Hori A, Seishima M, Tanabashi S, Matsushita S, and Nagata C. | Cancer Sci. 115 (5), 1688-1694. (2024) | | |
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| Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people. | | Koyanagi YN, Nakatochi M, Namba S, Oze I, Charvat H, Narita A, Kawaguchi T, Ikezaki H, Hishida A, Hara M, Takezaki T, Koyama T, Nakamura Y, Suzuki S, Katsuura-Kamano S, Kuriki K, Nakamura Y, Takeuchi K, Hozawa A, Kinoshita K, Sutoh Y, Tanno K, Shimizu A, Ito H, Kasugai Y, Kawakatsu Y, Taniyama Y, Tajika M, Shimizu Y, Suzuki E, Hosono Y, Imoto I, Tabara Y, Takahashi M, Setoh K; BioBank Japan Project; Matsuda K, Nakano S, Goto A, Katagiri R, Yamaji T, Sawada N, Tsugane S, Wakai K, Yamamoto M, Sasaki M, Matsuda F, Okada Y, Iwasaki M, Brennan P, Matsuo K | Sci Adv. 10(4), eade2780. (2024) | | |
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| jMorp: Japanese Multi-Omics Reference Panel update report 2023. | | Tadaka S, Kawashima J, Hishinuma E, Saito S, Okamura Y, Otsuki A, Kojima K, Komaki S, Aoki Y, Kanno T, Saigusa D, Inoue J, Shirota M, Takayama J, Katsuoka F, Shimizu A, Tamiya G, Shimizu R, Hiratsuka M, Motoike IN, Koshiba S, Sasaki M, Yamamoto M, and Kinoshita K. | Nucleic Acids Res. 52 (D1), D622-D632. (2024) | | |
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| Detection and correction of sample misidentifications in a biobank using the massarray system and genomic information. | | Kudo H, Ishida N, Nobukuni T, Aoki Y, Saito S, Nishijima I, Terakawa T, Yamamoto M, Minegishi N, Yamashita R, and Kumada K. | Biopreserv Biobank. 22 (4), 373-382. (2024) | | |
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Publications 2024 