Publications 2015 
 Original Paper
 
 
Identification of a Functional Antioxidant Response Element within the Eighth Intron of the Human ABCC3 Gene. 
Canet MJ, Merrell MD, Harder BG, Maher JM, Wu T, Lickteig AJ, Jackson JP, Zhang DD, Yamamoto M, Cherrington NJ.
Drug Metab Dispos   43(1), 93-99  (2015)
 
Progenitor stage-specific activity of acis-actingdouble GATA motif for Gata1 gene expression.  
Moriguchi T, Suzuki M, Yu L, Takai J, Ohneda K, and Yamamoto M
Mol Cell Biol   35(5), 805-815  (2015)
 
DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosyl methionine-producing metabolic pathway. 
Nishikawa K, Iwamoto Y, Kobayashi Y, Katsuoka F, Kawaguchi S-i, Tsujita T, Nakamura T, Kato S, Yamamoto M, Takayanagi H, and Ishii M.
Nature Med   21(3), 281-287  (2015)
 
In vivo regulation of erythropoiesis by chemically inducible dimerization of the erythropoietin receptor intracellular domain. 
Suzuki N, Mukai HY, and Yamamoto M.
PLoS One   10(3), e0119442  (2015)
 
MAFG is a transcriptional repressor of bile acid synthesis and metabolism. 
de Aguiar Vallim, TQ, Tarling, EJ, Ahn H, Hagey LR, Romanoski CE, Lee R, Graham M, Motohashi H, Yamamoto M, and Edwards PA.
Cell Metabolism   21(2), 298-310  (2015)
 
Hypoxia-sensitive reporter system for high-throughput screening. 
Tsujita T, Kawaguchi S, Dan T, Baird L, Miyata T, Yamamoto M.
Tohoku J Exp Med.    235(2), 151-159  (2015)
 
Alcohol dehydrogenase 3 contributes to the protection of liver from nonalcoholic steatohepatitis. 
Goto M, Kitamura H, Alam MM, Ota N, Haseba T, Akimoto T, Shimizu A, Takano-Yamamoto T, Yamamoto M, Motohashi H.
Genes Cells   20(6), 464-480  (2015)
大学院生後藤まきさんの論文です。
 
Discovery of an NRF1-specific inducer from a large-scale chemical library using a direct NRF1-protein monitoring system. 
Tsujita T, Baird L, Furusawa Y, Katsuoka F, Hou Y, Gotoh S, Kawaguchi SI, Yamamoto M.
Genes Cells.   20(7), 563-577  (2015)
 
The Human GATA1 Gene Retains a 5' Insulator That Maintains Chromosomal Architecture and GATA1 Expression Levels in Splenic Erythroblasts. 
Moriguchi T, Yu L, Takai J, Hayashi M, Satoh H, Suzuki M, Ohneda K, Yamamoto M.
Mol Cell Biol   35(10), 1825-1837  (2015)
 
Whole-body in vivo monitoring of inflammatory diseases exploiting human interleukin 6-luciferase transgenic mice. 
Hayashi M, Takai J, Yu L, Motohashi H, Moriguchi T, Yamamoto M.
Mol Cell Biol.   35(20), 3590-3601  (2015)
修士の林真貴子さんと卒業生高井淳さんの論文です。
 
Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation. 
Keleku-Lukwete N, Suzuki M, Otsuki A, Tsuchida K, Katayama S, Hayashi M, Naganuma E, Moriguchi T, Tanabe O, Engel JD, Imaizumi M, Yamamoto M.
Proc Natl Acad Sci U S A.   112(39), 12169-12174  (2015)
大学院生Nadineさんの論文です。
 
Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon. 
Rajendran P, Dashwood WM, Li L, Kang Y, Kim E, Johnson G, Fischer KA, Löhr CV, Williams DE, Ho E, Yamamoto M, Lieberman DA, Dashwood RH.
Clin Epigenetics.   7(1),   (2015)
 
In Vivo Spectrum of UVC-induced Mutation in Mouse Skin Epidermis May Reflect the Cytosine Deamination Propensity of Cyclobutane Pyrimidine Dimers. 
Ikehata H, Mori T, Yamamoto M.
Photochem Photobiol.    91(6), 1488-1496  (2015)
池畑広伸講師の論文です。
 
Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response. 
Saito R, Suzuki T, Hiramoto K, Asami S, Naganuma E, Suda H, Iso T, Yamamoto H, Morita M, Furusawa Y, Negishi T, Ichinose M, Yamamoto M.
Mol Cell Biol.    36(2), 271-284  (2015)
大学院生斎藤良太さんの論文です。
 
Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients. 
Kanamori M, Higa T, Sonoda Y, Murakami S, Dodo M, Kitamura H, Taguchi K, Shibata T, Watanabe M, Suzuki H, Shibahara I, Saito R, Yamashita Y, Kumabe T, Yamamoto M, Motohashi H, and Tominaga T.
Neuro Oncol   17, 555-565  (2015)
 
CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion.  
Zheng H, Fu J, Xue P, Zhao R, Dong J, Liu D, Yamamoto M, Tong Q, Teng W, Qu W, Zhang Q, Andersen ME, and Pi J.
Antioxid Redox Signal    22, 819-831  (2015)
 
12/15-Lipoxygenase-mediated enzymatic lipid oxidation regulates DC maturation and function.  
Rothe T, Gruber F, Uderhardt S, Ipseiz N, Rössner S, Oskolkova O, Blüml S, Leitinger N, Bicker W, Bochkov VN, Yamamoto M, Steinkasserer A, Schett G, Zinser E, and Krönke G.
J Clin Invest    125, 1944-1954  (2015)
 
GATA2 is critical for the maintenance of cellular identity in differentiated mast cells derived from mouse bone marrow.  
Ohmori S, Moriguchi T, Noguchi Y, Ikeda M, Kobayashi K, Tomaru N, Ishijima Y, Ohneda O, Yamamoto M, and Ohneda K.
Blood   125, 3306-3315  (2015)
 
Compound mouse mutants of bZIP transcription factors MafG and MafK reveal a regulatory network of non-crystallin genes associated with cataract. 
Agrawal SA, Anand D, Siddam AD, Kakrana A, Dash S, Scheiblin DA, Dang CA, Terrell AM, Waters SM, Singh A, Motohashi H, Yamamoto M, and Lachke SA.
Hum Genet    134, 717-735  (2015)
 
Hypoxia signaling cascade for erythropoietin production in hepatocytes.  
Tojo Y, Sekine H, Hirano I, Pan X, Souma T, Tsujita T, Kawaguchi S, Takeda N, Takeda K, Fong GH, Dan T, Ichinose M, Miyata T, Yamamoto M, and Suzuki N.
Mol Cell Biol    35, 2658-2672  (2015)
2014年卒業生、東條裕さんの論文です。
 
Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon. 
Rajendran P, Dashwood WM, Li L, Kang Y, Kim E, Johnson G, Fischer KA, Löhr CV, Williams DE, Ho E, Yamamoto M, Lieberman DA, and Dashwood RH.
Clin Epigenetics    7, 102, eCollection  (2015)
 
LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2.  
Takeuchi M, Fuse Y, Watanabe M, Andrea CS, Takeuchi M, Nakajima H, Ohashi K, Kaneko H, Kobayashi-Osaki M, Yamamoto M, and Kobayashi M.
Proc Natl Acad Sci USA   112, 13922-13927  (2015)
 
The mediator subunit MED16 transduces NRF2-activating signals into antioxidant gene expression. 
Sekine H, Okazaki K, Ota N, Shima H, Katoh Y, Suzuki N, Igarashi K, Ito M, Motohashi H, and Yamamoto M.
Mol Cell Biol    36(3), 407-420  (2015)
 
An integrative approach to analyze microarray datasets for prioritization of genes relevant to lens biology and disease. 
Anand D, Agrawal S, Siddam A, Motohashi H, Yamamoto M, Lachke SA.
Genom Data   5, 223-227  (2015)
 
The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap1. 
Ito A, Shimazu T, Maeda S, Shah AA, Tsunoda T, Iemura S, Natsume T, Suzuki T, Motohashi H, Yamamoto M, Yoshida M.
Sci Signal   8, ra120  (2015)

 Review
 
 
Part IV-17: Keap1-Nrf2 Regulatory System and Cancer 
Taguchi K, Yamamoto M.
Protein Modifications in Pathogenic Dysregulation of Signaling     (2015)
田口助教の総説です。
 
The Keap1-Nrf2 system and diabetes mellitus. 
Uruno A, Yagishita Y, Yamamoto M.
Arch Biochem Biophys.    566, 76-84  (2015)
宇留野講師の総説です。
 
Molecular basis of the Keap1-Nrf2 system. 
Suzuki T, Yamamoto M.
Free Radic Biol Med.    88, 93-100  (2015)
鈴木隆史助教の総説です。
 
Renal erythropoietin-producing cells in health and disease. 
Souma T, Suzuki N, Yamamoto M.
Front Physiol.   6, 00167, eCollection2015.  (2015)
研究員相馬友和さんの総説です。
 
Roles of renal erythropoietin-producing (REP) cells in the maintenance of systemic oxygen homeostasis. 
Suzuki N, Yamamoto M.
Pflugers Arch.    468(1), 3-12  (2015)
 
NRF2-mediated gene regulation and glucose homeostasis 
Yagishita Y, Uruno A, and Yamamoto M.
Diabetes and Nutrition      (2015)
 
GATA2, Atlas of Genetics and Cytogenetics in Oncology and Haematology  
Shimizu R. and Yamamoto M.
     (2015)
 
Leukemogenesis in Down syndrome. 
Shimizu R, and Yamamoto M.
In Health Problems in Down Syndrome.    Chapter 2  (2015)

 日本語著書 (Publications in Japanese)
 
 
EPO産生制御機構 
山本雅之、鈴木教郎、祢津昌広
腎と透析   79巻, 88-93  (2015)
 
肝疾患における転写因子Nrf2の機能変化, Clinical Topics 
田口恵子
別冊BIO Clinica   4(4), 159-161  (2015)
 
赤血球造血制御による個体レベルの酸素恒常性維持機構 
鈴木教郎
実験医学   33巻, 1724-1730  (2015)
 
赤血球増殖因子の産生機構の解明 
鈴木教郎
東北医学雑誌   127巻, 26-28  (2015)
 
造血因子エリスロポエチンを産生する細胞の単離解析 
鈴木教郎
東北医学雑誌   127巻, 59-60  (2015)
 
腎線維化と腎性貧血 
鈴木教郎、相馬友和
日腎会誌      ()
 
トランスオミクス解析が切り拓く次世代医療におけるバイオマーカー探索 
三枝大輔
JSBMS Letter   40, No3, 36-43  (2015)

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