Publications 2010 
 Original Paper
 
 
Role of Nrf2 and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells. 
Kosaka K, Mimura J, Itoh K, Satoh T, Shimojo Y, Kitajima C, Maruyama A, Yamamoto M, and Shirasawa T.

J Biochem   147, 73-81  (2010)
 
Loss of the Gata1 gene IE exon leads to variant transcript expression and the production of a GATA1 protein lacking the N-terminal domain. 
Kobayashi E, Shimizu R, Kikuchi Y, Takahashi S, and Yamamoto M.

J Biol Chem   285(1), 773-83.  (2010)
D2小林さんの論文です
 
NF-E2-related factor 2 regulates the stress response to UVA-1-oxidized phospholipids in skin cells.  
Gruber, F., Mayer, H., Lengauer, B., Mlitz, V., Sanders, J.M., Kadl, A., Bilban, M., de Martin, R., Wagner, O., Kensler, T.W., Yamamoto, M., Leitinger, N., Tschachler, E.
FASEB J    24(1), 39-48  (2010)
 
Suppression of AhR signaling pathway is associated with the down-regulation of UDP-glucuronosyltransferases during BBN-induced urinary bladder carcinogenesis in mice. 
Iida, K., Mimura, J., Itoh, K., Ohyama, C., Fujii-Kuriyama, Y., Shimazui, T., Akaza, H., Yamamoto M.
J. Biochem   147(3), 353-360  (2010)
 
NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation. 
Motohashi, H., Kimura, M., Fujita, R., Inoue, A., Pan, X., Takayama, M., Katsuoka, F., Aburatani, H., Bresnick, E.H., Yamamoto, M.
Blood   115(3), 677-686  (2010)
 
Indispensable function for embryogenesis, expression and regulation of the nonspecific form of the 5-aminolevulinate synthase gene in mouse 
Okano, S., Zhou, L., Kusaka, T., Shibata, K., Shimizu, K., Gao, X., Kikuchi ,Y., Togashi, Y., Hosoya, T., Takahashi, S., Nakajima, O., Yamamoto, M.
Genes Cells   15(1), 77-89  (2010)
 
Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease 
Rojo, A.I., Innamorato, N.G., Martín-Moreno, A.M., De Ceballos, M.L., Yamamoto, M., Cuadrado, A
Glia   58(5), 588-598  (2010)
 
Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice 
Sugimoto, H., Okada, K., Shoda, J., Warabi, E., Ishige, K., Ueda, T., Taguchi, K., Yanagawa, T., Nakahara, A., Hyodo, I., Ishii, T., Yamamoto, M
Am. J. Physiol. Gastrointest. Liver Physiol   298(2), G283-294  (2010)
 
Fractionation of mature eosinophils in GATA-reporter transgenic mice 
Kim, K., Suzuki, N., Ohneda, K., Minegishi, N., Yamamoto, M
Tohoku J. Exp. Med   220(2), 127-138  (2010)
 
Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains 
Ogura, T., Tong, K.I., Mio, K., Maruyama, Y., Kurokawa, H., Sato, C., Yamamoto, M
Proc. Natl. Acad. Sci. USA   107(7), 2842-2847  (2010)
 
A novel type of E3 ligase for the Ufm1 conjugation system. 
Tatsumi, K., Sou, Y.S., Tada, N., Nakamura, E., Iemura, S., Natsume, T., Kang, S.H., Chung, C.H., Kasahara, M., Kominami, E., Yamamoto, M., Tanaka, K., Komatsu, M
J. Biol. Chem   285(8), 5417-5427  (2010)
辰巳さん (筑波大D4) の論文です
 
Efficient transient rescue of hematopoietic mutant phenotypes in zebrafish using Tol2-mediated transgenesis 
Takeuchi, M., Kaneko, H., Nishikawa, K., Kawakami, K., Yamamoto, M., Kobayashi, M.: Efficient transient rescue of hematopoietic mutant phenotypes in zebrafish using Tol2-mediated transgenesis
Dev. Growth Differ   52(2), 245-250  (2010)
竹内さん (筑波大D4) の論文です
 
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 
Komatsu, M., Kurokawa, H., Waguri, S., Taguchi, K., Kobayashi, A., Ichimura, Y., Sou, Y.S., Ueno, I., Sakamoto, A., Tong, K.I., Kim, M., Nishito, Y., Iemura, S., Natsume, T., Ueno, T., Kominami, E., Motohashi, H., Tanaka, K., Yamamoto, M
Nat. Cell. Biol   12(3), 213-223  (2010)
 
The Transcriptome of Nrf2-/- Mice Provides Evidence for Impaired Cell Cycle Progression in the Development of Cigarette-Smoke-Induced Emphysematous Changes.  
Gebel, S., Diehl, S., Pype, J., Friedrichs, B., Weiler, H., Schüller, J., Xu, H., Taguchi, K., Yamamoto, M., Müller, T.
Toxicol. Sci.   115(1), 238-52  (2010)
 
Role of Nrf2 in retinal vascular development and the vaso-obliterative phase of oxygen-induced retinopathy. 
Uno, K., Prow, T.W., Bhutto, I.A., Yerrapureddy, A., McLeod, D.S., Yamamoto, M., Reddy, S.P., Lutty, G.A.
Exp Eye Res.   90(4), 493-500  (2010)
 
Genetic analysis of hierarchical regulation for Gata1 and NF-E2 p45 gene expression in megakaryopoiesis. 
Takayama M, Fujita R, Suzuki M, Okuyama R, Aiba S, Motohashi H, Yamamoto M.
Mol Cell Biol.   30(11), 2668-2680  (2010)
高山さんの論文です
 
Genetic analysis of cytoprotective functions supported by graded expression of Keap1. 
Taguchi K, Maher JM, Suzuki T, Kawatani Y, Motohashi H, Yamamoto M.
Mol Cell Biol   30(12), 3016-3026  (2010)
田口助教の論文です
 
Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver. 
Kitteringham NR, Abdullah A, Walsh J, Randle L, Jenkins RE, Sison R, Goldring CE, Powell H, Sanderson C, Williams S, Higgins L, Yamamoto M, Hayes J, Park BK.
J Proteomics.   73, 1612-31  (2010)
 
Cytochrome P450 2A5 constitutive expression and induction by heavy metals is dependent on redox-sensitive transcription factor Nrf2 in liver. 
Lämsä V, Levonen AL, Leinonen H, Ylä-Herttuala S, Yamamoto M, Hakkola J.
Chem Res Toxicol.   23, 977-85.  (2010)
 
The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway. 
Shah ZA, Li RC, Ahmad AS, Kensler TW, Yamamoto M, Biswal S, Doré S.
J Cereb Blood Flow Metab.   30, 1951-61.  (2010)
 
Ablation of the transcription factor Nrf2 promotes ischemia-induced neovascularization by enhancing the inflammatory response. 
Ichihara S, Yamada Y, Liu F, Murohara T, Itoh K, Yamamoto M, Ichihara G.
Arterioscler Thromb Vasc Biol.   30, 1553-61.  (2010)
 
The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response. 
Fujii S, Sawa T, Ihara H, Tong KI, Ida T, Okamoto T, Ahtesham AK, Ishima Y, Motohashi H, Yamamoto M, Akaike T.
J Biol Chem.   285, 23970-84  (2010)
 
Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung. 
Satoh H, Moriguchi T, Taguchi K, Takai J, Maher JM, Suzuki T, Winnard PT Jr, Raman V, Ebina M, Nukiwa T, Yamamoto M.
Carcinogenesis.   31, 1833-43  (2010)
佐藤さん(医員)の論文です。
 
Suppression of SLC11A2 expression is essential to maintain duodenal integrity during dietary iron overload. 
Shirase T, Mori K, Okazaki Y, Itoh K, Yamamoto M, Tabuchi M, Kishi F, Jiang L, Akatsuka S, Nakao K, Toyokuni S.
Am J Pathol.   177, 677-85  (2010)
 
Regulation of notch1 signaling by nrf2: implications for tissue regeneration. 
Wakabayashi N, Shin S, Slocum SL, Agoston ES, Wakabayashi J, Kwak MK, Misra V, Biswal S, Yamamoto M, Kensler TW.
Sci Signal.   3, ra52  (2010)
 
Dual-color luciferase mouse directly demonstrates coupled expression of two clock genes. 
Noguchi T, Michihata T, Nakamura W, Takumi T, Shimizu R, Yamamoto M, Ikeda M, Ohmiya Y, Nakajima Y.
Biochemistry.   49, 8053-61  (2010)
 
Nrf2 is closely related to allergic airway inflammatory responses induced by low-dose diesel exhaust particles in mice. 
Li YJ, Takizawa H, Azuma A, Kohyama T, Yamauchi Y, Takahashi S, Yamamoto M, Kawada T, Kudoh S, Sugawara I.
Clin Immunol.   137, 234-41  (2010)
 
Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthracene. 
Becks L, Prince M, Burson H, Christophe C, Broadway M, Itoh K, Yamamoto M, Mathis M, Orchard E, Shi R, McLarty J, Pruitt K, Zhang S, Kleiner-Hancock HE.
BMC Cancer.   10, 540  (2010)
 
Global downstream pathway analysis reveals a dependence of oncogenic NF-E2-related factor 2 mutation on the mTOR growth signaling pathway. 
Shibata T, Saito S, Kokubu A, Suzuki T, Yamamoto M, Hirohashi S.
Cancer Res.   70, 9095-105  (2010)
 
Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1/Th2 balance. 
Kikuchi N, Ishii Y, Morishima Y, Yageta Y, Haraguchi N, Itoh K, Yamamoto M, Hizawa N.
Respir Res.   11, 31  (2010)
 
Increased susceptibility of Nrf2-null mice to 1-bromopropane-induced hepatotoxicity. 
Liu F, Ichihara S, Valentine WM, Itoh K, Yamamoto M, Sheik Mohideen S, Kitoh J, Ichihara G.
Toxicol Sci.   115, 596-606  (2010)

 日本語著書 (Publications in Japanese)
 
 
酸化ストレスと呼吸器疾患 
井上大輔、本橋ほづみ、山本雅之
分子呼吸器病   14(1), 6-7  (2010)
 
エリスロポエチン産生細胞 
峯岸直子、山本雅之
臨床血液   51, 1607-15  (2010)
 
酸化ストレスセンサーKeap1と選択的オートファジー基質p62複合体の結晶構造 
黒河博文
日本結晶学会誌   52, 250-4  (2010)
 
ストレスと生体反応 Nrf2-Keap1システムによるストレス応答制御 
宇留野晃、森口尚、山本雅之
Diabetes Frontier   21, 412-7  (2010)
 
Gata1遺伝子血球系制御領域の赤血球分化段階特異的な機能解析 
鈴木未来子
東北医学会雑誌   122, 37-40  (2010)

 Review
 
 
GATA1 and GATA2 function in hematopoietic differentiation 
Moriguchi, T., Suzuki, M., Engel, J.D., Yamamoto, M.
Hematopoietic Stem Cell Biol.   1, 117-142  (2010)
 
The rise of antioxidant signaling-The evolution and hormetic actions of Nrf2 
Maher, J., Yamamoto M.
Toxicol. Appl. Pharmacol.   244(1), 4-15  (2010)
 
Nrf2 in toxicology and pharmacology: The good, the bad and the ugly? 
Pi, J., Freeman, M.L., Yamamoto, M.
Toxicol. Appl. Pharmacol.   244(1), 1-3  (2010)
 
GATA factor switching during erythroid differentiation.  
Kaneko H, Shimizu R, Yamamoto M.
Curr Opin Hematol.   17(3), 163-8  (2010)
 
Discovery of the negative regulator of Nrf2, Keap1: a historical overview. 
Itoh K, Mimura J, Yamamoto M.
Antioxid Redox Signal.   13, 1665-78  (2010)
 
MafB as a type I interferon rheostat. 
Motohashi H, Igarashi K.
Nat Immunol.   11, 695-6  (2010)

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