Program

Sunday morning, 26 October

GATA functions
Chairperson: Doug Engel

9:00 Roger Patient: Introduction remarks.
9:15 Stuart Orkin: Genetic analysis of GATA-1.
9:45 Gary Felsenfeld: GATA-1 and chromatin structure.
10:15 Dave Whyatt: GATA-1 and cell cycle.

10:30 Coffee Break

11:00 Dick Flavell: The role of GATA-3 in CD4 T-cell differentiation.
11:30 Alar Karis: The role of GATA-3 in mouse development.
11:45 Roger Patient: GATA effects on cell fate and differentiation.

12:30 Group Photo

Sunday evening, 26 October

Blood
Chairperson: Stuart Orkin
5:00 Frank Grosveld: GATA factors and globin gene regulation.
5:30 Alice Tsang: Function of friend of GATA-1 (FOG) in hematopoiesis.
5:50 Thomas Graf: Role of GATA1, C/EBP and PU.1 in lineage
determination of hematopoietic progenitors.

6:20 Break
6:35 Tariq Enver: Transcriptional programming in haematopoietic stem cells.
7:05 Leonard Zon: Role of GATA-binding proteins as hematopoietic specifiers during
embryogenesis.

Monday morning, 27 October

Genetic analysis
Chairperson: Nigel Holder

8:45 Herbert Arst: Mutational analysis of the DNA binding region of the GATA factor
AreA, mediating nitrogen metabolite repression in Aspergillus.
9:15 Iain Manfield: The DNA-binding domain of the gene regulatory protein AreA
extends beyond the minimal zinc finger region conserved between GATA proteins.
9:30 Joel Rothman: Specification of the endoderm by a GATA factor in the nematode
C. elegans.

10:30 Coffee Break

11:00 Pat Simpson: The role of pannier and itﾕs co-factor U-shape in the regulation
of achaete-scute expression and bristle pattern in Drosphila.
11:30 Rolf Reuter: Serpent, a GATA factor for blood and gut in flies.
12:00 Cecelia Trainer: The role of ﾔdoubleﾕ DNA binding sites in gene regulation
by GATA factors.

Monday evening, 27 October

Regulation of GATA expression
Chairperson: Gray Felsenfeld

5:00 Masayuki Yamamoto: Upstream and downstream of erythroid transcription
factor GATA-1.
5:30 Sergio Ottolenghi: Multiple regulatory elements within the mouse GATA-1 gene.
6:00 Anna Rita Migliaccio: The increase in the expression of GATA-1 during erythroid differentiation is mediated by activation of its distal promoter.
6:15 Maggie Walmsley: Patterning of GATA-2 and 3 in the non-neural ectoderm.

6:30 Break

6:45 Matthew Guille: Regulation of Xenopus GATA-2 gene by a developmentally regulated CCAAT box transcription factor.
7:00 Doug Engel: GATA-2 and GATA-3 YACs.
7:30 John Burch: Heart-region ﾐspecific control of GATA-6 gene expression.

Tuesday morning, 28 October

Heart and endoderm
Chairperson: Roger Patient

8:45 Mona Nemer: Molecular basis for GATA factor specificity.
9:15 Frederic Charron: Differentiation of in vivo targets for GATA factors in the myocardium.
9:30 Michael S. Parmacek: Structure, function and expression of GATA-6 in vertebrate development.
10:00 Todd Evans: Distinct functions for GATA-4/5/6 in the heart and gut.

10:30 Coffee Break

11:00 Markku Heikinheimo: Transcription factors GATA-4 and 6 in the endocrine system.
11:30 Masatomo Maeda: Gastric GATA-6 DNA-binding protein: proteolysis induced by cAMP.
11:45 Nigel Holder: The spatial regulation of GATA gene expression in the zebrafish gastrula.

Poster viewing before and after evening sessions.

This Workshop has been sponsored by
European Molecular Biololgy Organization (EMBO)

The Organizers wish to gratefully acknowledge the cooperation of the AZIENDA AUTONOMA DI CURA. SOGGIORNO E TURISMO. Capri